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Chemical Structure : Autotaxin inhibitor 12
Catalog No.: PC-35168Not For Human Use, Lab Use Only.
Autotaxin inhibitor 12 is a highly potent, selective, orally-bioavailable inhibitor of autotaxin with IC50 of 3.1 nM in choline release assays.
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Autotaxin inhibitor 12 is a highly potent, selective, orally-bioavailable inhibitor of autotaxin with IC50 of 3.1 nM in choline release assays.
Autotaxin inhibitor 12 shows ATX inhibition of IC50 9 nM in an in vitro serum assay, measuring 18:1 LPA levels by LCMS.
Autotaxin inhibitor 12 concentration-dependently inhibits autotaxin and formation of LPA in vivo.
| M.Wt | 440.325 | |
| Formula | C19H23Cl2N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thomson CG, et al. Bioorg Med Chem Lett. 2018 May 21. pii: S0960-894X(18)30431-1.
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