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Azadiradione

Chemical Structure : Azadiradione

CAS No.: 26241-51-0

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Azadiradione

Catalog No.: PC-27695Not For Human Use, Lab Use Only.

Azadiradione is a tetranortriterpenoid from Azadirachta indica, directly interacts with purified human heat shock factor 1 (HSF1) with high specificity, potentiates HSF1 DNA binding activity, activates HSF1 and its target heat shock chaperone genes.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Azadiradione is a tetranortriterpenoid from Azadirachta indica, directly interacts with purified human heat shock factor 1 (HSF1) with high specificity, potentiates HSF1 DNA binding activity, activates HSF1 and its target heat shock chaperone genes.

Physicochemical Properties

M.Wt 450.58
Formula C28H34O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(5R,7R,8R,9R,10R,13S,17R)-17-(Furan-3-yl)-4,4,8,10,13-pentamethyl-3,16-dioxo-4,5,6,7,8,9,10,11,12,13,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-7-yl acetate

References

1. Siddiqui S, et al. J Nat Prod. 1992 Mar;55(3):303-10.

2. Govindachari TR, et al. Fitoterapia. 2000 Jun;71(3):317-20.

3. Nelson VK, et al. Oncotarget. 2016 Nov 29;7(48):78281-78296.

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