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Chemical Structure : Azeloprazole
Catalog No.: PC-60032Not For Human Use, Lab Use Only.
A novel potent proton pump inhibitor that irreversibly inhibits H+,K+-ATPase activity with IC50 of 0.28 uM.
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A novel potent proton pump inhibitor that irreversibly inhibits H+,K+-ATPase activity with IC50 of 0.28 uM; inhibits histamine-stimulated gastric acid secretion with ED50 of 0.18-0.2 mg/kg in gastric fistula model in dogs, displays 2.3-fold more potency over Esomeprazole.
Other Indication
Phase 1 Clinical
| M.Wt | 429.535 | |
| Formula | C22H27N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Kodama K, et al. J Pharmacol Exp Ther. 2010 Aug;334(2):395-401.
2. Toda R, et al. J Clin Pharmacol. 2017 Nov 28. doi: 10.1002/jcph.1038.
3. Toda R, et al. Xenobiotica. 2017 Nov 2:1-15. doi: 10.1080/00498254.2017.1390625.
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