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Chemical Structure : BAN ORL 24
CAS No.: 1401463-54-4
Catalog No.: PC-43402Not For Human Use, Lab Use Only.
BAN ORL 24 is a potent, selective, non-peptide nociceptin/orphanin FQ receptor (NOP receptor, ORL1) antagonist with IC50 of 0.27 nM, displays no significant activity for κ-, μ- and δ-receptors.
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|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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BAN ORL 24 is a potent, selective, non-peptide nociceptin/orphanin FQ receptor (NOP receptor, ORL1) antagonist with IC50 of 0.27 nM, displays no significant activity for κ-, μ- and δ-receptors.
BAN ORL 24 produces a concentration-dependent displacement of [(3)H]N/OFQ binding to CHO(hNOP) cell membranes with pKi of 9.62 and selectivity (1000 fold) over classical opioid receptors.
BAN ORL 24 antagonizes the pronociceptive and antinociceptive effects of N/OFQ in vivo.
| M.Wt | 506.5076 | |
| Formula | C27H37Cl2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Pyrrolidinecarboxamide, 1-(phenylmethyl)-N-(3-spiro[isobenzofuran-1(3H),4'-piperidin]-1'-ylpropyl)-, (2R)- |
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1. Fischetti C, et al. Eur J Pharmacol. 2009 Jul 1;614(1-3):50-7.
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