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Chemical Structure : BAY-1436032
Catalog No.: PC-60292Not For Human Use, Lab Use Only.
BAY-1436032 (BAY1436032) is a potent, selective, orally available inhibitor of pan-mutant IDH1 with IC50 of 15 nM for both IDH1 R132H and R132C, respectively.
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BAY-1436032 (BAY1436032) is a potent, selective, orally available inhibitor of pan-mutant IDH1 with IC50 of 15 nM for both IDH1 R132H and R132C, respectively; shows no effect on wild-type IDH1; strongly reduces 2-HG levels in cells carrying IDH1-R132H, -R132C, -R132G, -R132S and -R132L mutations; significantly prolongs survival of mice intracerebrally transplanted with human astrocytoma carrying the IDH1R132H mutation.
Blood Cancer
Phase 1 Clinical
| M.Wt | 489.54 | |
| Formula | C26H30F3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Pusch S, et al. Acta Neuropathol. 2017 Apr;133(4):629-644.
2. Chaturvedi A, et al. Leukemia. 2017 Oct;31(10):2020-2028.
3. Gokul S, et al. CNS Neurol Disord Drug Targets. 2017;16(6):636-637.
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