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BAY-320

Chemical Structure : BAY-320

CAS No.: 1445830-50-1

BAY-320 (BAY320)

Catalog No.: PC-35361Not For Human Use, Lab Use Only.

BAY-320 (BAY320) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 680 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BAY-320 (BAY320) is a potent, selective, ATP-competitive inhibitor of Bub1 kinase with IC50 of 680 nM.
    BAY-320 displays modest cross reactivity with a panel of 222 kianses at 10 uM.
    BAY-320 reduces T120 phosphorylation of histone H2A in intact cells, affects chromosome association of Shugoshin proteins and the chromosomal passenger complex (CPC), without abolishing global Aurora B function, impairs chromosome arm resolution with minor effects on mitotic progression or SAC function.
    BAY-320 sensitizes cells to Paclitaxel, impairing both chromosome segregation and cell proliferation.

    Physicochemical Properties

    M.Wt 492.531
    Formula C26H26F2N6O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-[5-cyclopropyl-1-(4-ethoxy-2,6-difluorobenzyl)-4-methyl-1H-pyrazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine

    References

    1. Baron AP, et al. Elife. 2016 Feb 17;5. pii: e12187.

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