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Chemical Structure : BAY-405
Catalog No.: PC-49661Not For Human Use, Lab Use Only.
BAY-405 (BAY405) is a potent, selective MAP4K1 (HPK1) inhibitor, displays potent nanomolar MAP4K1 inhibition in biochemical and cellular assays, inhibits SLP76 phosphorylation with submicromolar potency and shows good kinase selectivity.
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BAY-405 (BAY405) is a potent, selective MAP4K1 (HPK1) inhibitor, displays potent nanomolar MAP4K1 inhibition in biochemical and cellular assays, inhibits SLP76 phosphorylation with submicromolar potency and shows good kinase selectivity.
BAY-405 enhances T-cell immunity and overcomes the suppressive impact of PGE2, TGFβ and CD4+ T-regulatory cells.
BAY-405 demonstrated single-agent efficacy in syngeneic EMT6 breast and B16-OVA melanoma mouse models, as well as benefits when combined with anti-PDL1 Ab in the B16-OVA model.
| M.Wt | 522.48 | |
| Formula | C25H23F5N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Leder, G. et al. Enhancement of anti-tumor T-cell immunity by means of an oral small molecule targeting the intracellular immune checkpoint MAP4K1. Cancer Res. 81 (Suppl. 13), Abstr. 1722 (2021).
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