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Chemical Structure : BAY-8040
Catalog No.: PC-60472Not For Human Use, Lab Use Only.
BAY-8040 (BAY8040) is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM.
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BAY-8040 (BAY8040) is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM.
BAY-8040 displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases.
BAY-8040 shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension.
| M.Wt | 427.387 | |
| Formula | C21H16F3N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. von Nussbaum F, et al. ChemMedChem. 2016 Jan 19;11(2):199-206.
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