Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BAY-826
Catalog No.: PC-35106Not For Human Use, Lab Use Only.
BAY-826 (BAY826) is a novel selective, highly potent, orally available TIE-2 inhibitor (dissociation constant=1.6 nM).
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BAY-826 (BAY826) is a novel selective, highly potent, orally available TIE-2 inhibitor (dissociation constant=1.6 nM); binds with similar high affinity to only 4 of 456 kinases, namely, TIE-1,DDR1, DDR2, and LOK (dissociation constant=0.9, 0.4, 1.3, and 5.9 nM), BAY-826 is highly selective against other angiogenic kinases, such as VEGFR, FGFR, or PDGFR, and affects VEGF-stimulated proliferation of HUVEC only at lM concentrations; inhibits TIE-2 phosphorylation in vitro and in vivo as demonstrated by suppression of Angiopoietin-1- or Na3 VO4 -induced TIE-2 phosphorylation in glioma cells or extracts of lungs from BAY-826-treated mice; improves tumor control in syngeneic mouse glioma models.
| M.Wt | 558.531 | |
| Formula | C26H19F5N6OS | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Schneider H, et al. J Neurochem. 2017 Jan;140(1):170-182.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
