Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : BAY-9835
Catalog No.: PC-21753Not For Human Use, Lab Use Only.
BAY-9835 is the first orally bioavailable, potent and selective inhibitor of dual matrix metalloprotease ADAMTS7/ADAMTS12 with IC50 of 6 nM/30 nM respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
BAY-9835 is the first orally bioavailable, potent and selective inhibitor of dual matrix metalloprotease ADAMTS7/ADAMTS12 with IC50 of 6 nM/30 nM respectively.
BAY-9835 displays >1000-fold selectivity over ADAMTS4/ADAMTS5, and >300-fold selective over ADAM8/10/17, and MMP2/12/14/15.
BAY-9835 shows low clearance, high oral bioavailability, and good tolerability in a 2-week toxicology study in rats.
| M.Wt | 493.39 | |
| Formula | C22H16F5N5O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. Meibom D, et al. J Med Chem. 2024 Feb 13. doi: 10.1021/acs.jmedchem.3c02036.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
