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Chemical Structure : BAY 11-7085
CAS No.: 196309-76-9
Catalog No.: PC-42493Not For Human Use, Lab Use Only.
BAY 11-7085 is an inhibitor of the expression of ICAM-1, VCAM-1, and E-selectin in human endothelial cells (IC50=5-10 uM), acts by selectively inhibiting TNFα-induced phosphorylation of IκB-α without affecting the constitutive IκB-α phosphorylation.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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BAY 11-7085 is an inhibitor of the expression of ICAM-1, VCAM-1, and E-selectin in human endothelial cells (IC50=5-10 uM), acts by selectively inhibiting TNFα-induced phosphorylation of IκB-α without affecting the constitutive IκB-α phosphorylation.
BAY 11-7085 prevents PMA-induced NF-kappaB nuclear translocation.
BAY 11-7085 reduces swelling in both the rat carrageenan paw edema assay and in a rat adjuvant arthritis model.
| M.Wt | 249.3287 | |
| Formula | C13H15NO2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 26 mg/mL |
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| Chemical Name/SMILES |
2-Propenenitrile, 3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-, (2E)- |
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1. Pierce JW, et al. J Biol Chem. 1997 Aug 22;272(34):21096-103.
2. Hu X, et al. Cancer Res. 2001 Aug 15;61(16):6290-6.
3. Vielma SA, et al. Circ Res. 2003 May 30;92(10):1130-7.
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