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Chemical Structure : BAY1214784
Catalog No.: PC-38730Not For Human Use, Lab Use Only.
BAY 1214784 (BAY-784) is an orally available, potent, and selective antagonist of gonadotropin-releasing hormone receptor (GnRH-R) with IC50 of 21/ 24/ 35 nM for human/rat/cynomolgus GnRH-R, respectively.
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BAY 1214784 (BAY-784) is an orally available, potent, and selective antagonist of gonadotropin-releasing hormone receptor (GnRH-R) with IC50 of 21/ 24/ 35 nM for human/rat/cynomolgus GnRH-R, respectively.
BAY 1214784 showed no agonistic activity in the human GnRH-R up to 20 uM, and was inactive in a cell-based panel of 25 GPCRs.
BAY 1214784 (10 and 30 mg/kg, p.o.) demonstrated suppression of plasma luteinizing hormone levels in OVX rats and ORX cynomolgus monkeys.
| M.Wt | 672.11 | |
| Formula | C29H26ClF4N3O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Panknin O, et al. J Med Chem. 2020 Oct 22;63(20):11854-11881.
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