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Chemical Structure : BAY1217389
CAS No.: 1554458-53-5
Catalog No.: PC-43262Not For Human Use, Lab Use Only.
BAY1217389 (BAY-1217389) is a potent, selective Monopolar spindle 1 (Mps1/TTK) inhibitor with IC50 of 0.63 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $148 | In stock | |
| 10 mg | $258 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BAY1217389 (BAY-1217389) is a potent, selective Monopolar spindle 1 (Mps1/TTK) inhibitor with IC50 of 0.63 nM.
BAY1217389 shows excellent kinase selectivity in DiscoveRx kinase panel (395 kinases), with exception of PDGFRβ (<10 nM), Kit (10-100 nM).
BAY1217389 abrogates nocodazole-induced metaphase arrest in HeLa cells with IC50 of 0.11 nM, inhibits the proliferation of a panel tumor cell lines covering various cancer with IC50 of 3-300 nM.
BAY1217389 enhances the efficacy of antimitotic cancer drugs and shows potentially overcome resistance in vivo.
| M.Wt | 561.5032 | |
| Formula | C27H24F5N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methyl- |
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1. Wengner AM, et al. Mol Cancer Ther. 2016 Apr;15(4):583-92.
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