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BAY 2686013

Chemical Structure : BAY 2686013

CAS No.:

BAY 2686013 (BAY2686013)

Catalog No.: PC-20945Not For Human Use, Lab Use Only.

BAY 2686013 is a selective, allosteric antagonist of human pituitary adenylate cyclase activating polypeptide receptor (hPAC1-R) with IC50 of 0.92 and 0.4 uM in cAMP HTRF and Ca2+ release assays, respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BAY 2686013 is a selective, allosteric antagonist of human pituitary adenylate cyclase activating polypeptide receptor (hPAC1-R) with IC50 of 0.92 and 0.4 uM in cAMP HTRF and Ca2+ release assays, respectively.
BAY 2686013 is a valuable tool compound for better understanding the signalling and function of hPAC1-R.

Physicochemical Properties

M.Wt 392.30
Formula C17H14F6N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

O=C(NC1=CC=C(OCC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C=C1)CN

References

1. Gernot Langer, et al. Mol Pharmacol. 2023 Jun 22;MOLPHARM-AR-2022-000662.

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