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Chemical Structure : BAY38-7271
Catalog No.: PC-21983Not For Human Use, Lab Use Only.
BAY 38-7271 is selective, highly potent and cannabinoid CB1/CB2 receptor agonist with 0.46-1.85 nM for rat brain, human cortex, or recombinant human CB1 receptors.
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BAY 38-7271 is selective, highly potent and cannabinoid CB1/CB2 receptor agonist with 0.46-1.85 nM for rat brain, human cortex, or recombinant human CB1 receptors.
BAY 38-7271 shows high affinity to cannabinoid CB2 receptors (Ki=6 nM, recombinant human cannabinoid CB2 receptor).
BAY 38-7271 induced a dose-dependent reduction in body temperature (minimal effective dose = 6 μg/kg, i.v.) in rat hypothermia assays.
BAY 38-7271 demonstrated highly potent and efficient neuroprotective properties in rat traumatic brain injury model.
BAY 38-7271 shows pronounced neuroprotective properties that do not result from drug-induced hypothermia, devoid of typical cannabinoid-like side effects.
| M.Wt | 430.44 | |
| Formula | C20H21F3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Mauler F, et al. BAY 38-7271: a novel highly selective and highly potent cannabinoid receptor agonist for the treatment of traumatic brain injury. CNS Drug Rev. 2003 Winter;9(4):343-58.
2. Mauler F, et al. J Pharmacol Exp Ther. 2002 Jul;302(1):359-68.
3. De Vry J, et al. Eur J Pharmacol. 2002 Dec 20;457(2-3):147-52.
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