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Chemical Structure : BAY 60-7550
Catalog No.: PC-22039Not For Human Use, Lab Use Only.
BAY 60-7550 (Bay60-7550) is a potent and selective PDE2 inhibitor with Ki of 3.8 nM, IC50 of 4.7 nM (human PDE2A), and 2.0 nM (bovine purified PDE2).
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BAY 60-7550 (Bay60-7550) is a potent and selective PDE2 inhibitor with Ki of 3.8 nM, IC50 of 4.7 nM (human PDE2A), and 2.0 nM (bovine purified PDE2).
BAY 60-7550 displays 50-fold selectivity over PDE1, and 100-800-fold over other PDEs.
BAY 60-7550 enhances long-term potentiation of synaptic transmission without altering basal synaptic transmission in cultured neurons and hippocampal slices.
BAY 60-7550 improves the performance of rats in social and object recognition memory tasks, and reversed MK801-induced deficits in spontaneous alternation in mice in a T-maze.
| M.Wt | 476.58 | |
| Formula | C27H32N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Boess FG, et al. Neuropharmacology. 2004 Dec;47(7):1081-92.
2. Castro LR, et al. Circulation. 2006 May 9;113(18):2221-8.
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