Catalog No.: PC-38449Not For Human Use, Lab Use Only.
BC-1258 is a specific small molecule FBXO3 inhibitor and F-box/LRR-repeat protein 2 (FBXL2) activator, BC-1258 is sufficient to stabilize and upregulate FBXL2 levels, selectively induces Aurora B degradation in vitro and in vivo.
BC-1258 is a specific small molecule FBXO3 inhibitor and F-box/LRR-repeat protein 2 (FBXL2) activator, BC-1258 is sufficient to stabilize and upregulate FBXL2 levels, selectively induces Aurora B degradation in vitro and in vivo.
BC-1258 induced FBXL2 concentrations in a variety of cells, decreased FBXL2 substrates, including Aurora B in human leukemia cells.
BC-1258 induced apoptosis in leukemic cells by causing mitotic arrest and tetraploidy.
BC-1258 prematurely depleted Aurora B by SCFFBXL2-induced ubiquitination and degradation, BC-1258 (30 ug/ml in the drinking water) showed significant decreases in Aurora B protein levels and inhibited tumorigenesis on growth of U937 tumor implants in nude mice.
