Chemical Structure : BCFTP
CAS No.:
2781215-95-8
BCFTP
Catalog No.: PC-25931Not For Human Use, Lab Use Only.
BCFTP is a specific, orally bioavailable positive allosteric modulator of Mas-related G protein-coupled receptor X1 (MrgprX1), BCFTP selectively potentiates the functional response of MrgprX1 in HEK293 cells.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BCFTP is a specific, orally bioavailable positive allosteric modulator of Mas-related G protein-coupled receptor X1 (MrgprX1), BCFTP selectively potentiates the functional response of MrgprX1 in HEK293 cells.
Oral administration of BCFTP dose-dependently inhibited heat hyperalgesia and spontaneous pain-like behavior but not mechanical hypersensitivity after sciatic chronic constrictive injury (CCI) in MrgprX1 mice.
BCFTP enhanced BAM8-22–induced, MrgprX1-mediated reduction of C-fiber eEPSC amplitudes in spinal lamina II neurons, indicating inhibition of spinal nociceptive synaptic transmission.
BCFTP ameliorated certain pain-related behaviors in transgenic mice expressing the human receptor but did not induce itch, a common side effect of agonists for this receptor family.
Physicochemical Properties
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M.Wt
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496.90
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Formula
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C23H17ClF4N2O2S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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6-tert-butyl-5-(4-chlorophenyl)-4-(2-fluoro-6-(trifluoromethoxy)phenoxy)thieno[2,3-d]pyrimidine
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References
1. Uniyal A, et al. Sci Transl Med. 2025 Dec 17;17(829):eadw9446.
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