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Chemical Structure : BCX-1470
Catalog No.: PC-45881Not For Human Use, Lab Use Only.
BCX-1470 (BCX1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM).
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BCX-1470 (BCX1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM).
BCX-1470 displays 3.4-fold and 200-fold bette than that of trypsin, respectively.
BCX-1470 inhibits esterolytic activity translates into potent inhibition of the proteolytic activity of C1s, factor D, and consequently of the classical and alternative pathway-mediated hemolysis of target RBC (IC50=46 nM and 330 nM, respectively).
BCX-1470 blocks the reverse passive Arthus (RPA) reaction in rats.
| M.Wt | 302.3714 | |
| Formula | C14H10N2O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Szalai AJ, et al. J Immunol. 2000 Jan 1;164(1):463-8.
2. Babu, Y. S, et al. Patent No. WO 98/55471.
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