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BDM71339

Chemical Structure : BDM71339

CAS No.: 2580938-64-1

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BDM71339 (BDM 71339)

Catalog No.: PC-49180Not For Human Use, Lab Use Only.

BDM71339 is the first small molecule inhibitor of mycobacterial transcriptional regulator EthR, boosts ten times the activity of ethionamide in TB-infected macrophages at low nanomolar concentrations (EC50=72 nM) in vitro.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BDM71339 is the first small molecule inhibitor of mycobacterial transcriptional regulator EthR, boosts ten times the activity of ethionamide in TB-infected macrophages at low nanomolar concentrations (EC50=72 nM) in vitro.
BDM71339 is active in vivo in acute model of tuberculosis infection.

Physicochemical Properties

M.Wt 325.291
Formula C15H14F3N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)-N-(3,3,3-trifluoropropyl)benzamide

References

1. Baptiste Villemagne, et al. ACS Infect Dis. 2020 Mar 13;6(3):366-378.

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