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BDM88855 hydrochloride

Chemical Structure : BDM88855 hydrochloride

CAS No.: 2892824-26-7

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BDM88855 hydrochloride (BDM 88855 hydrochloride)

Catalog No.: PC-72796Not For Human Use, Lab Use Only.

BDM88855 Hcl is a novel allosteric efflux-pump inhibitor that potentiate antibiotic activity in E. coli through inhibition of its primary RND transporter, AcrAB-TolC.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    BDM88855 Hcl is a novel allosteric efflux-pump inhibitor that potentiate antibiotic activity in E. coli through inhibition of its primary RND transporter, AcrAB-TolC.
    BDM88855 binds to a unique site on the transmembrane domain of the AcrB L protomer, lined by key catalytic residues involved in proton relay, boost antibiotic activity in E. coli by inhibiting the AcrAB-TolC efflux pump.

    Physicochemical Properties

    M.Wt 284.184
    Formula C13H15Cl2N3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Quinoline, 3-chloro-2-(1-piperazinyl)-, hydrochloride (1:1)

    References

    1. Coline Plé, et al. Nat Commun. 2022 Jan 10;13(1):115.

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