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BDM88855 hydrochloride

Chemical Structure : BDM88855 hydrochloride

CAS No.: 2892824-26-7

BDM88855 hydrochloride (BDM 88855 hydrochloride)

Catalog No.: PC-72796Not For Human Use, Lab Use Only.

BDM88855 Hcl is a novel allosteric efflux-pump inhibitor that potentiate antibiotic activity in E. coli through inhibition of its primary RND transporter, AcrAB-TolC.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

BDM88855 Hcl is a novel allosteric efflux-pump inhibitor that potentiate antibiotic activity in E. coli through inhibition of its primary RND transporter, AcrAB-TolC.
BDM88855 binds to a unique site on the transmembrane domain of the AcrB L protomer, lined by key catalytic residues involved in proton relay, boost antibiotic activity in E. coli by inhibiting the AcrAB-TolC efflux pump.

Physicochemical Properties

M.Wt 284.184
Formula C13H15Cl2N3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Quinoline, 3-chloro-2-(1-piperazinyl)-, hydrochloride (1:1)

References

1. Coline Plé, et al. Nat Commun. 2022 Jan 10;13(1):115.

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