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Chemical Structure : BFL-1 inhibitor 4E14
Catalog No.: PC-72541Not For Human Use, Lab Use Only.
4E14 (BFL-1 BH3 inhibitor 4E14) is a potent, covalent BFL-1 (BCL2A1 or A1) inhibitor that disrupt BH3-binding activity with IC50 of 23 nM (FITC-BID BH3/BFL-1 interaction).
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4E14 (BFL-1 BH3 inhibitor 4E14) is a potent, covalent BFL-1 (BCL2A1 or A1) inhibitor that disrupt BH3-binding activity with IC50 of 23 nM (FITC-BID BH3/BFL-1 interaction).
4E14 targets a unique C55 residue in the BFL-1 groove.
4E14 blocks BFL-1 suppression of BAX-mediated mitochondrial apoptosis.
4E14 (BFL-1 BH3 inhibitor 4E14) blocks BFL-1 suppression of BAX-mediated mitochondrial apoptosis.
| M.Wt | 408.579 | |
| Formula | C19H28N4O2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Edward P Harvey, et al. Cell Chem Biol. 2020 Jun 18;27(6):647-656.e6.
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