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Chemical Structure : BGP-15
CAS No.: 66611-37-8
Catalog No.: PC-42269Not For Human Use, Lab Use Only.
BGP-15 is a PARP inhibitor and an inducer of HSF-1/HSP72 (cotreatment with heat) in vtiro, has no effect on HSP90 levels.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $258 | In stock | |
| 100 mg | Get quote |
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BGP-15 is a PARP inhibitor and an inducer of HSF-1/HSP72 (cotreatment with heat) in vtiro, has no effect on HSP90 levels.
BGP-15 markedly increases the phosphorylation of HSF1 and expression of HSF1 and HSP72 in adipocytes and muscle cells.
BGP-15 protects against obesity-induced insulin resistance and orally active.
BGP-15 alleviates ventilation-induced diaphragm dysfunction associated with HSP72 induction and PARP-1 inhibition.
| M.Wt | 351.272 | |
| Formula | C14H24Cl2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 11.33 mg/mL |
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| Chemical Name/SMILES |
3-Pyridinecarboximidamide, N-[2-hydroxy-3-(1-piperidinyl)propoxy]-, hydrochloride (1:2) |
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1. Salah H, et al. Sci Transl Med. 2016 Aug 3;8(350):350ra103.
2. Chung J, et al. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1739-44.
3. Racz I, et al. Biochem Pharmacol. 2002 Mar 15;63(6):1099-111.
4. Kardon T, et al. Anticancer Res. 2006 Mar-Apr;26(2A):1023-8.
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