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Chemical Structure : BI-2536
CAS No.: 755038-02-9
Catalog No.: PC-45847Not For Human Use, Lab Use Only.
BI-2536 is a potent and selective inhibitor of PLK1 with IC50 of 0.83 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $218 | In stock | |
| 100 mg | Get quote |
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BI-2536 is a potent and selective inhibitor of PLK1 with IC50 of 0.83 nM.
BI-2536 also weakly inhibits the activities of PLK2 and PLK3 (IC50=3.5 nM and 9.0 nM, respectively), displays >1,000-fold selectivity to a panel of 63 other protein kinases.
BI-2536 causes a mitotic arrest and induces apoptosis in human cancer cell lines, inhibits growth of human tumor xenografts in nude mice and induces regression of large tumors with well-tolerated intravenous dose regimens.
BI-2536 also inhibits BRD4 with IC50 of 25 nM.
| M.Wt | 521.6544 | |
| Formula | C28H39N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, 4-[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)- |
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1. Steegmaier M, et al. Curr Biol. 2007 Feb 20;17(4):316-22. Epub 2007 Feb 8.
2. Chen L, et al. ACS Med Chem Lett. 2015 May 18;6(7):764-9.
3. Nappi TC, et al. Cancer Res. 2009 Mar 1;69(5):1916-23.
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