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Chemical Structure : BI-D1870
CAS No.: 501437-28-1
Catalog No.: PC-42627Not For Human Use, Lab Use Only.
BI-D1870 is a potent, specific ATP-competitive inhibitor of RSK isoforms with IC50 of 10-30 nM for RSK1/2/3/4.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $158 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $398 | In stock | |
| 100 mg | Get quote |
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BI-D1870 is a potent, specific ATP-competitive inhibitor of RSK isoforms with IC50 of 10-30 nM for RSK1/2/3/4.
BI-D1870 shows weak inhibition on PLK1 (IC50=100 nM) and no activity against MSK1.
BI-D1870 prevents the RSK-mediated phorbol ester- and EGF-induced phosphoryl-ation of GSK-3β and LKB1 in human embry-onic kidney 293 cells and Rat-2 cells.
| M.Wt | 391.415 | |
| Formula | C19H23F2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
6(5H)-Pteridinone, 2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)- |
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1. Sapkota GP, et al. Biochem J. 2007 Jan 1;401(1):29-38.
2. Neise D, et al. Cell Death Dis. 2013 Oct 17;4:e859.
3. Fonseca BD, et al. J Biol Chem. 2011 Aug 5;286(31):27111-22.
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