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Chemical Structure : BI1002494
Catalog No.: PC-70329Not For Human Use, Lab Use Only.
BI1002494 (BI-1002494) is a novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin).
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BI1002494 (BI-1002494) is a novel, potent, and selective spleen tyrosine kinase (SYK) inhibitor with enzyme IC50 of 30 nM, cell IC50 of 7 nM (FcεR1-mediated histamine release in human monocyte-derived mast cells, in the presence of 0.1% albumin).
BI1002494 inhibits high-affinity IgE receptor-mediated mast cell and basophil degranulation (IC50=115 nM), 7-fold lower potency for blocking CD69 expression after anti-IgD (BCR) stimulation of peripheral B cells.
BI1002494 dose-dependently inhibited OVA-induced bronchioalveolar lavage eosinophils in brown Norway rats.
| M.Wt | 423.469 | |
| Formula | C23H25N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lamb DJ, et al. J Pharmacol Exp Ther. 2016 Jun;357(3):554-61.
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