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Chemical Structure : BI 665915
Catalog No.: PC-35038Not For Human Use, Lab Use Only.
BI 665915 is a highly potent, selective, orally active 5-lipoxygenase-activating protein (FLAP) inhibitor with binding IC50 of 1.7 nM.
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BI 665915 is a highly potent, selective, orally active 5-lipoxygenase-activating protein (FLAP) inhibitor with binding IC50 of 1.7 nM.
BI 665915 displays no activity against other enzymes and receptors in the leukotriene pathway such as 5-LO, COX-1 and -2, phospholipase A2, LTA4 hydrolase, BLT1, and BLT2 (IC50s>10 uM).
BI 665915 shows functional inhibition of LTB4 production in human whole blood (IC50=45 nM).
BI 665915 demonstrates a dose-dependent DMPK relationship and inhibition of LTB4 production in vivo.
| M.Wt | 458.526 | |
| Formula | C24H26N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Takahashi H, et al. J Med Chem. 2015 Feb 26;58(4):1669-90.
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