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Chemical Structure : BIIB021
CAS No.: 848695-25-0
Catalog No.: PC-42459Not For Human Use, Lab Use Only.
BIIB021 is a potent, selective, orally available HSP90 inhibitor with Ki of 1.7 nM for Hsp90α.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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BIIB021 is a potent, selective, orally available HSP90 inhibitor with Ki of 1.7 nM for Hsp90α.
BIIB021 displays no significant activity against a broad panel of protein kinases, and Na+K+ ATPase.
BIIB021 induces the degradation of Hsp90 client proteins including HER-2, AKT, and Raf-1 and upregulates expression of Hsp70 and Hsp27 in tumor cells.
BIIB021 inhibits cell growth and induces cell death in cell lines from a variety of tumor types at nanomolar concentrations (IC50=60 nM in N87 cells).
BIIB021 exhibits antitumor effects in vivo.
| M.Wt | 318.7615 | |
| Formula | C14H15ClN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 45 mg/mL |
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| Chemical Name/SMILES |
9H-Purin-2-amine, 6-chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]- |
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1. Kasibhatla SR, et al. J Med Chem. 2007 Jun 14;50(12):2767-78.
2. Lundgren K, et al. Mol Cancer Ther. 2009 Apr;8(4):921-9.
3. Böll B, et al. Clin Cancer Res. 2009 Aug 15;15(16):5108-16.
4. Gopalakrishnan R, et al. Clin Cancer Res. 2013 Sep 15;19(18):5016-26.
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