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Chemical Structure : BIO-7488
Catalog No.: PC-21921Not For Human Use, Lab Use Only.
BIO-7488 (BIO7488) is the first potent, selective, and CNS-penetrant IRAK4 inhibitor with IC50 of 0.5 nM (1 mM ATP).
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BIO-7488 (BIO7488) is the first potent, selective, and CNS-penetrant IRAK4 inhibitor with IC50 of 0.5 nM (1 mM ATP).
BIO-7488 potently inhibits R848 stimulus of 1L-1β production with IC50 of 200 nM in human whole blood assay.
BIO-7488 has limited MDR1 or BCRP efflux liability, supporting the favorable measured rat Kpu,u of 0.3 in rats.
BIO-7488 (10, 30, or 100 mg/kg) demonstrated robust and dose-dependent suppression of multiple cytokines, including IL-1β, TNFα, and IL-6 in LPS challenge rat model.
| M.Wt | 447.50 | |
| Formula | C23H25N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ryan Evans, et al. J Med Chem. 2024 Mar 11. doi: 10.1021/acs.jmedchem.3c02226.
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