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Chemical Structure : BIO
CAS No.: 667463-62-9
Catalog No.: PC-42664Not For Human Use, Lab Use Only.
A cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $96 | In stock | |
| 50 mg | $360 | In stock |
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A cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM; also inhibit CDK1/Cyclin B and CDK5/p25 (IC50, 320 nM and 83 nM); maintains the undifferentiated phenotype in HESCs and MESCs, sustains the expression of Oct-3/4, Rex-1 and Nanog; promotes proliferation in mammalian cardiomyocytes.
| M.Wt | 356.1735 | |
| Formula | C16H10BrN3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 23 mg/mL |
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| Chemical Name/SMILES |
2H-Indol-2-one, 6-bromo-3-[(3E)-1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-, (3Z)- |
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1. Meijer L, et al. Chem Biol. 2003 Dec;10(12):1255-66.
2. Tseng AS, et al. Chem Biol. 2006 Sep;13(9):957-63.
3. Sato N, et al. Nat Med. 2004 Jan;10(1):55-63.
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