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BIO1211

Chemical Structure : BIO1211

CAS No.: 187735-94-0

BIO1211 (BIO-1211;BIO 1211)

Catalog No.: PC-35546Not For Human Use, Lab Use Only.

BIO1211 (BIO-1211) is a potent, highly specific integrin α4β1 (VLA-4) inhibitor with Kd/IC50 of 20 pM/4 nM for the activated form of α4β1.

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Biological Activity

BIO1211 (BIO-1211) is a potent, highly specific integrin α4β1 (VLA-4) inhibitor with Kd/IC50 of 20 pM/4 nM for the activated form of α4β1.
BIO1211 displays >200-fold selectivity over a range of other integrins (IC50 >100 uM for α1β1, α5β1 and α6β1), and reacts only with activated VLA4。
BIO1211 inhibits ovalbumin-induced lung inflammation in vivo.

Physicochemical Properties

M.Wt 708.813
Formula C36H48N6O9
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Proline, N-[[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]-L-leucyl-L-a-aspartyl-L-valyl- (9CI)

References

1. Chen LL, et al. J Biol Chem. 1999 May 7;274(19):13167-75.

2. Chen LL, et al. J Biol Chem. 2001 Sep 28;276(39):36520-9.

3. Koo GC, et al. Am J Respir Crit Care Med. 2003 May 15;167(10):1400-9.

4. Karanam BV, et al. Xenobiotica. 2007 May;37(5):487-502.

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