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Chemical Structure : BIRT-377
Catalog No.: PC-73252Not For Human Use, Lab Use Only.
BIRT-377 (BIRT377) is a potent, orally active negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) with Kd of 26 nM.
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BIRT-377 (BIRT377) is a potent, orally active negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) with Kd of 26 nM.
BIRT-377 (BIRT377) is a binds to the I-domain of LFA-1.
BIRT 377 reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1.
BIRT-377 (BIRT377) is a inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro.
BIRT-377 (BIRT377) attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo.
| M.Wt | 442.13 | |
| Formula | C18H15BrCl2N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chowdari NS, et al. Org Lett. 2005 Mar 3;7(5):867-70.
2. Larson RS, et al. Biochemistry. 2005 Mar 22;44(11):4322-31.
3. Sanchez JJ, et al. Acta Neuropathol Commun. 2019 Apr 8;7(1):54.
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