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Chemical Structure : BIX 02565
CAS No.: 1311367-27-7
Catalog No.: PC-21764Not For Human Use, Lab Use Only.
BIX 02565 is a potent, selective ribosomal S6 kinase 2 (RSK2) inhibitor with IC50 of 1.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 10 mg | $298 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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BIX 02565 is a potent, selective ribosomal S6 kinase 2 (RSK2) inhibitor with IC50 of 1.1 nM.
BIX 02565 is 100-fold selective relative to RSK for a kinase panel, with the exception of LRRK2 and PRKD1, for which showed 16- and 35-fold selectivity.
BIX 02565 (1, 3, and 10 mg/kg) in the rat CV screen resulted in a precipitous decrease in both mean arterial pressure (MAP; to -65 ± 6 mm Hg below baseline) and heart rate (-93 ± 13 beats/min).
BIX 02565 (30, 100, and 300 mg/kg p.o. QD for 4 days) elicited concentration-dependent decreases in MAP in telemetry-instrumented rats.
| M.Wt | 458.57 | |
| Formula | C26H30N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(5R)-N-[1-[3-(Dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide |
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1. Thomas M Kirrane, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):738-42.
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