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Chemical Structure : BIX02694
Catalog No.: PC-20447Not For Human Use, Lab Use Only.
BIX02694 (BIX 02694) is a highly potent, in vivo-active GPR5 (GPBAR1) agonist with EC50 of 9 nM in AlphaScreen cAMP assays.
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BIX02694 (BIX 02694) is a highly potent, in vivo-active GPR5 (GPBAR1) agonist with EC50 of 9 nM in AlphaScreen cAMP assays.
BIX02694 cross reacts with mouse GPBAR1 and can impact monocyte response to LPS.
BIX02694 reduces monocyte activation in vitro and proinflammatory cytokine production in vivo reduces EAE disease severity.
| M.Wt | 491.03 | |
| Formula | C28H31ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nuruddeen D Lewis, et al. PLoS One. 2014 Jun 26;9(6):e100883.
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