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Chemical Structure : BK-1361
CAS No.: 1975145-82-4
Catalog No.: PC-60981Not For Human Use, Lab Use Only.
BK-1361 (BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
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| 50 mg | Get quote | ||
| 100 mg | Get quote |
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BK-1361 (BK1361, cyclo-RLsKDK) is a cyclic peptide with RLsKDK (s=D-serine) that functions as a potent, selective inhibitor of ADAM8 with IC50 of 120 nM.
BK-1361 displays no significant activity against ADAM 9, 10, 12, 17 , as well as MMP-2, -9, and -14 at 10 uM.
BK-1361 inhibits shedding of CD23 with IC50 of 182 nM in cell-based shedding assays, reduces migration/invasion of pancreatic cancer cells and less ERK1/2 and MMP activation, causes change in cell morphology.
BK-1361 decreases tumour burden and metastasis of implanted pancreatic tumour cells and provides improved metrics of clinical symptoms and survival in Kras(G12D)-driven mouse model of PDAC.
| M.Wt | 727.865 | |
| Formula | C31H57N11O9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
cyclo-RLsKDK; s=D-serine |
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1. Schlomann U, et al. Nat Commun. 2015 Jan 28;6:6175.
2. Chen J, et al. Sci Rep. 2016 Jul 26;6:30451.
3. Yim V, et al. Bioorg Med Chem. 2016 Sep 15;24(18):4032-4037.
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