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Chemical Structure : BL-140
Catalog No.: PC-60391Not For Human Use, Lab Use Only.
BL-140 is a potent, specific p110β inhibitor with IC50 of 5.74 nM.
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BL-140 is a potent, specific p110β inhibitor with IC50 of 5.74 nM.
BL-140 dispalys 150-fold and 745-fold selectivity over p110α or p110δ.
BL-140 blocks G1 phase cell cycle entry by reducing cyclin D1 but increasing p27kip1 protein levels, overcomes MDV3100-resistance in castration-resistant prostate cancer cells.
| M.Wt | 371.459 | |
| Formula | C18H21N5O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. He C, et al. Prostate. 2017 Aug;77(11):1187-1198.
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