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BL-918

Chemical Structure : BL-918

CAS No.: 2101517-69-3

BL-918 (BL918)

Catalog No.: PC-63368Not For Human Use, Lab Use Only.

BL-918 is a small molecule activator of ULK1 with EC50 of 24 nM (243% kinase activity at 100 nM), induces autophagy via the ULK complex in SH-SY5Y cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BL-918 is a small molecule activator of ULK1 with EC50 of 24 nM (243% kinase activity at 100 nM), induces autophagy via the ULK complex in SH-SY5Y cells.
BL-918 displays a cytoprotective effect on MPP+-treated SH-SY5Y cells, as well as protected against MPTP-induced motor dysfunction and loss of dopaminergic neurons by targeting ULK1-modulated autophagy in mouse models of PD.

Physicochemical Properties

M.Wt 533.44
Formula C23H15F8N3OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-2-(3-(3,5-Bis(trifluoromethyl)phenyl)thioureido)-N-(2,4-difluorophenyl)-2-phenylacetamide

References

1. Ouyang L, et al. J Med Chem. 2018 Apr 12;61(7):2776-2792.

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