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Chemical Structure : BLM inhibitor 2
Catalog No.: PC-72682Not For Human Use, Lab Use Only.
BLM inhibitor 2 is a specific inhibitor of BLM (Bloom syndrome protein) ATPase-coupled DNA helicase activity (IC50=2.2 uM) via the allosteric binding site.
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BLM inhibitor 2 is a specific inhibitor of BLM (Bloom syndrome protein) ATPase-coupled DNA helicase activity (IC50=2.2 uM) via the allosteric binding site.
BLM inhibitor 2 displays high selectivity over members of the RecQ-helicase family in ATP-turnover assays, including recombinant helicase domains (HD) from human WRN, human RecQ5 or E. coli helicase UvrD, and human RecQ1.
BLM inhibitor 2 is a non-competitive inhibitor, does not interfere with ATP-binding, unliker ML216.
BLM inhibitor 2 inhibits production of the single-stranded DNA product in a dose-dependent manner (IC50=1.8 uM) via inhibition of the helicase activity of BLM-HD.
BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates (BLM, WRN, RECQ1, RECQ4, and RECQ5 in humans).
| M.Wt | 401.499 | |
| Formula | C19H19N3O3S2 | |
| Appearance | Solid | |
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1. Xiangrong Chen, et al. Elife. 2021 Mar 1;10:e65339.
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