Chemical Structure : BM-51
CAS No.:
3038211-56-9
BM-51
(BM51)
Catalog No.: PC-27980Not For Human Use, Lab Use Only.
BM-51 is a potent, specific inhibitor of cytochrome P450 enzyme CYP4Z1 with IC50 of 91.7 nM, shows high selectivity against CYP4 isozymes (>100 folds).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
BM-51 is a potent, specific inhibitor of cytochrome P450 enzyme CYP4Z1 with IC50 of 91.7 nM, shows high selectivity against CYP4 isozymes (>100 folds).
BM-51 attenuatees the tumor-initiating cells (TICs)-like traits of breast cancer cells.
BM-51 suppresses the progression and the function of PyMT-induced TICs in PyMT-CYP4Z1-KI mice and chemosensitivity of breast cancer cells.
BM-51 significantly inhibits the tumor-initiating ability of breast cancer cells and expression of stemness markers.
CYP4Z1 promotes breast cancer progression by enhancing TIC-like traits, promoting a de-differentiated and invasive phenotype, and reprogramming lipid metabolism.
Physicochemical Properties
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M.Wt
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285.39
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Formula
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C17H23N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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Benzeneacetamide, 4-(1H-imidazol-1-ylmethyl)-N-(1-methylbutyl)-
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References
1. Yuan Y, et al. Exp Mol Med. 2026 Jul;58(7):2202-2222.
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