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Chemical Structure : BML-284
CAS No.: 853220-52-7
Catalog No.: PC-45774Not For Human Use, Lab Use Only.
BML-284 (AMBMP) is a potent selective, and cell-permeable canonical Wnt/β-catenin pathway activator with EC50 of 0.7 uM (induces beta-catenin- and TCF-dependent transcriptional activity).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $98 | In stock | |
| 50 mg | $158 | In stock | |
| 100 mg | $258 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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BML-284 (AMBMP) is a potent selective, and cell-permeable canonical Wnt/β-catenin pathway activator with EC50 of 0.7 uM (induces beta-catenin- and TCF-dependent transcriptional activity).
BML-284 induces the rapid phosphorylation of NFκB p65 at Ser536 and abrogates total IκB, accompanied by a subsequent increase in pro-inflammatory cytokine production (TNF, IL-6, IL-12 p40) in otherwise naive monocytes.
AMBMP treatment activates CaMKII and metabolically reprograms skeletal muscle toward a slow muscle phenotype.
| M.Wt | 350.3712 | |
| Formula | C19H18N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 30 mg/mL |
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| Chemical Name/SMILES |
2,4-Pyrimidinediamine, N4-(1,3-benzodioxol-5-ylmethyl)-6-(3-methoxyphenyl)- |
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1. Liu J, et al. Angew Chem Int Ed Engl. 2005 Mar 18;44(13):1987-90.
2. Denicol AC, et al. Sci Rep. 2013;3:1266. doi: 10.1038/srep01266.
3. Wang H, et al. Inflamm Res. 2016 Jan;65(1):61-9.
4. Liu J, et al. Cell Rep Med. 2020 Oct 20;1(7):100122.
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