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BMS-242

Chemical Structure : BMS-242

CAS No.: 1675204-51-9

BMS-242 (BMS 242;BMS242)

Catalog No.: PC-70032Not For Human Use, Lab Use Only.

A potent PD-1/PD-L1 interaction inhibitor with IC50 of 6-100 nM in a homogenous time-resolved fluorescence binding assay..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent PD-1/PD-L1 interaction inhibitor with IC50 of 6-100 nM in a homogenous time-resolved fluorescence binding assay.

Physicochemical Properties

M.Wt 449.591
Formula C28H35NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-2-((2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)amino)-3-methylbutan-1-ol

References

1. Guzik K, et al. J Med Chem. 2017 Jul 13;60(13):5857-5867.

2. Zak KM, et al. Oncotarget. 2016 May 24;7(21):30323-35.

3. Chupak, L.S., and Zheng, X. Compounds useful as immunomodulators. PCT/US2014/053695, (2015).

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