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Chemical Structure : BMS-332
Catalog No.: PC-21532Not For Human Use, Lab Use Only.
BMS-332 (BMS332) is a potent, selective dual DGKα/ζ inhibitor with IC50 of 9/8 nM respectively.
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BMS-332 (BMS332) is a potent, selective dual DGKα/ζ inhibitor with IC50 of 9/8 nM respectively.
BMS-332 displays >100-fold selectivity over the related DGK type I family members DGKβ and DGKγ.
BMS-332 exhibits IC50 values of 5 nM and 1 nM in the YFP-DGKα and YFP-DGKζ high-content translocation assays, respectively.
| M.Wt | 499.57 | |
| Formula | C29H27F2N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wichroski M, et al. Sci Transl Med. 2023;15(719):eadh1892.
2. L. Chupak, et al. ACS Med. Chem. Lett. 14, 929–935 (2023).
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