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Chemical Structure : BMS-457
Catalog No.: PC-63566Not For Human Use, Lab Use Only.
BMS-457 is a potent and selective CCR1 antagonist with binding IC50 of 0.8 nM, >1,000-fold selectivity against other CC family receptors.
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BMS-457 is a potent and selective CCR1 antagonist with binding IC50 of 0.8 nM, >1,000-fold selectivity against other CC family receptors.
BMS-457 displays single-digit nanomolar inhibition of chemotaxis induced by a number of CCR1 ligands, including MIP-1α( IC50=2.1 nM), Leukotactin-1 (IC50=4.4 nM), RANTES (IC50=1.0 nM), MPIF-1 (IC50=2.7 nM), and HCC-1 (IC50=4.0 nM).
BMS-457 blocks the ligand-stimulated upregulation of the β2-integrin CD11b in whole blood, with IC50 of 46 nM (MIP-1α) and 54 nM (LKN-1).
| M.Wt | 451.004 | |
| Formula | C24H35ClN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gardner DS, et al. Bioorg Med Chem Lett. 2013 Jul 1;23(13):3833-40.
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