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BMS-582949

Chemical Structure : BMS-582949

CAS No.: 623152-17-0

BMS-582949 (BMS 582949)

Catalog No.: PC-21600Not For Human Use, Lab Use Only.

BMS-582949 is a potent, selective and orally active p38α MAP kinase inhibitor with IC50 of 13 nM, exhibits significant inhibition of TNFα release in hPBMC with IC50 of 50 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

BMS-582949 is a potent, selective and orally active p38α MAP kinase inhibitor with IC50 of 13 nM, exhibits significant inhibition of TNFα release in hPBMC with IC50 of 50 nM.

Physicochemical Properties

M.Wt 406.49
Formula C22H26N6O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-((5-(Cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide

References

1. Liu C, et al. J Med Chem. 2010 Sep 23;53(18):6629-39.

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