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Chemical Structure : BMS-737
Catalog No.: PC-49301Not For Human Use, Lab Use Only.
BMS-737 (BMS737) is a potent, , selective, non-steroidal, reversible inhibitor of CYP17 lyase, 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase.
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BMS-737 (BMS737) is a potent, , selective, non-steroidal, reversible inhibitor of CYP17 lyase, 11-fold selectivity for CYP17 lyase over CYP17 hydroxylase.
BMS-737 demonstrates a robust 83% lowering of testosterone without any significant perturbation of the mineralocorticoid and glucocorticoid levels in cynomologous monkeys in a 1-day PK/PD study.
| M.Wt | 306.304 | |
| Formula | C16H11FN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Padmakar Darne C, et al. Bioorg Med Chem Lett. 2022 Aug 27;75:128951.
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