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Chemical Structure : BMS-816336
Catalog No.: PC-60349Not For Human Use, Lab Use Only.
BMS-816336 is a novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM.
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BMS-816336 is a novel potent, selective, orally active human 11β-HSD1 inhibitor with IC50 of 3.0 nM.
BMS-816336 displays >10,000-fold selectivity over huma 11β-HSD2.
BMS-816336 exhibits a robust acute pharmacodynamic effect in cynomolgus monkeys (ED50=0.12 mg/kg) and in DIO mice.
| M.Wt | 341.451 | |
| Formula | C21H27NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ye XY, et al. J Med Chem. 2017 Jun 22;60(12):4932-4948.
2. Maxwell BD. J Labelled Comp Radiopharm. 2017 Jun 30;60(8):357-365.
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