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Chemical Structure : BMS-817399
CAS No.: 1202400-18-7
Catalog No.: PC-35036Not For Human Use, Lab Use Only.
BMS-817399 is a potent, selective, orally bioavailable CCR1 antagonist with binding IC50 of 1 nM, inhibits MIP-1α-induced chemotaxis with IC50 of 6 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $298 | In stock | |
| 10 mg | $488 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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BMS-817399 is a potent, selective, orally bioavailable CCR1 antagonist with binding IC50 of 1 nM, inhibits MIP-1α-induced chemotaxis with IC50 of 6 nM.
BMS-817399 shows no binding activity to other CC family receptors, including CCR2, CCR3, CCR4, CCR5, CXCR2, CXCR3, and CXCR5, as well as a broad panel of other GPCRs and biogenic amine transporters.
BMS-817399 blocks MIP1α- and LKN-1-mediated up-regulation of CD11b in human whole blood with IC50 values of 25 nM and 42 nM, respectively.
BMS-817399 shows potential for the treatment of rheumatoid arthritis.
| M.Wt | 454.008 | |
| Formula | C23H36ClN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-((R)-1-((S)-4-(4-chlorophenyl)-4-hydroxy-3,3-dimethylpiperidin-1-yl)-3-methyl-1-oxobutan-2-yl)-3-(2-hydroxy-2-methylpropyl)urea |
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1. Santella JB 3rd, et al. J Med Chem. 2014 Sep 25;57(18):7550-64.
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