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Chemical Structure : BMS-818251
Catalog No.: PC-35935Not For Human Use, Lab Use Only.
BMS-818251 (BMS818251) is a novel potent, small-molecule inhibitor of HIV-1 entry with EC50 of 0.019 nM against e laboratory-adapted HIV-1 strain NL4-3.
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BMS-818251 (BMS818251) is a novel potent, small-molecule inhibitor of HIV-1 entry with EC50 of 0.019 nM against laboratory-adapted HIV-1 strain NL4-3.
BMS-818251 displays >10-fold more potent than Temsavir (BMS-626529, Cat# PC-38563) on a cross-clade panel of 208-HIV-1 strains.
BMS-818251 interacts with gp120 residues from the conserved β20-β21 hairpin to improve potency.
| M.Wt | 570.624 | |
| Formula | C29H26N6O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Lai YT, et al. Nat Commun. 2019 Jan 3;10(1):47. doi: 10.1038/s41467-018-07851-1.
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