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Chemical Structure : BMS-869780
Catalog No.: PC-62911Not For Human Use, Lab Use Only.
BMS-869780 is a potent γ-secretase modulator (GSM) that decreases Aβ1-42 (IC50=5.1 nM) and Aβ1-40 (IC50=25.1 nM) and increases Aβ1-37 and Aβ1-38 without inhibiting overall levels of Aβ peptides or other APP processing intermediates.
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BMS-869780 is a potent γ-secretase modulator (GSM) that decreases Aβ1-42 (IC50=5.1 nM) and Aβ1-40 (IC50=25.1 nM) and increases Aβ1-37 and Aβ1-38 without inhibiting overall levels of Aβ peptides or other APP processing intermediates.
BMS-869780 does not inhibit Notch processing by γ-secretase and loweres brain Aβ1-42 without evidence of Notch-related side effects in rats.
BMS-869780 shows synergistic inhibition of Aβ combined with GSM-2.
| M.Wt | 452.918 | |
| Formula | C23H22ClFN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Toyn JH, et al. Int J Alzheimers Dis. 2014;2014:431858.
2. Robertson AS, et al. Eur J Pharmacol. 2017 Oct 5;812:104-112.
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