BMS-906024
(Osugacestat; AL 101; BMS 906024; BMS906024)
Catalog No.: PC-60478Not For Human Use, Lab Use Only.
Osugacestat (AL 101, BMS-906024) is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively.
Osugacestat (AL 101, BMS-906024) is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively.
Osugacestat (AL 101, BMS-906024) exhibits >200-fold selectivity against a panel of diverse protein targets.
Osugacestat (AL 101, BMS-906024) inhibits both leukemia (TALL-1) and triple-negative breast cancer (MDA-MB-468) cells with IC50 of 0.4 nM, demonstrates broad-spectrum antineoplastic activity against a wide array of human cancer xenografts.
