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Chemical Structure : BMS-906024
Catalog No.: PC-60478Not For Human Use, Lab Use Only.
Osugacestat (AL 101, BMS-906024) is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively.
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Osugacestat (AL 101, BMS-906024) is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively.
Osugacestat (AL 101, BMS-906024) exhibits >200-fold selectivity against a panel of diverse protein targets.
Osugacestat (AL 101, BMS-906024) inhibits both leukemia (TALL-1) and triple-negative breast cancer (MDA-MB-468) cells with IC50 of 0.4 nM, demonstrates broad-spectrum antineoplastic activity against a wide array of human cancer xenografts.
| M.Wt | 556.5 | |
| Formula | C26H26F6N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gavai AV, et al. ACS Med Chem Lett. 2015 Mar 11;6(5):523-7.
2. Knoechel B, Cold Spring Harb Mol Case Stud. 2015 Oct;1(1):a000539.et al.
3. Morgan KM, et al. Mol Cancer Ther. 2017 Dec;16(12):2759-2769.
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